財團法人預防醫學基金會

Preventive Medicine Foundation


民國 105 年 04 月 15 日

 

本會協助臺北市政府辦理「臺北市新生兒危急型先天心臟病篩檢推廣計畫」的篩檢成果已共同發表於 2016 年 04 月 13 日之 PLOS ONE 國際期刊。

 

本會蕭廣仁執行長 ( Hsiao KJ ) 為本文通訊作者。

專案經理蕭郁詩 ( Shiau YS ) 與執行秘書蔣思慧 ( Chiang SH )為本文共同第一作者及第二作者。


http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0153407 


Tsao PC, Shiau YS, Chiang SH, Ho HC, Liu YL, Chung YF, Lin LJ, Chen MR, 
Chang JK, Soong WJ, Lin HL, Hwang B, Hsiao KJ.  Development of a Newborn Screening Program for Critical Congenital Heart Disease (CCHD) in Taipei.  PLoS One. 2016;11(4):e0153407.   doi: 10.1371/journal.pone.0153407

 

<ABSTRACT>

BACKGROUND:

Early detection of critical congenital heart disease (CCHD) can significantly reduce morbidity and mortality among newborns. We investigate the feasibility of implementing a community-based newborn CCHD screening program in Taipei.

METHODS:

Twelve birthing facilities in Taipei participated in a trial screening program between October 1, 2013, and March 31, 2014. Newborns underwent pulse oximetry at 24-36 h old, with probes attached to the right hand and one lower limb. Any screening saturation ≥95% in either extremity, with an absolute difference of ≤3% between the right hand and foot, was accepted as a screening pass. A screening result was considered as a fail if the oxygen saturation was <95% at either probe site, on 3 separate occasions, each separated by 30 min or the first result was <95% at either probe site, and any subsequent oxygen saturation measurement was <90%. Public health nurses would follow up all missed or refused cases.

RESULTS:

Of the 6,387 live births, 6,296 newborns (coverage rate: 6,296/6,387 = 98.6%) underwent appropriate pulse oximetry screening. Sixteen newborns (0.25%) were reported to have a failed screening result. Five of these screen positive newborns were confirmed with CCHD; two of them were diagnosed solely attributed to the failed screening results. The false-positive rate was 0.18%. Implementing a 6-month screening program for CCHD produced good case detection rate, while using efficient screening and referral systems.

CONCLUSION:

This program was successful in integrating screening, referral and public health tracking systems. The protocol outlined in this report could provide a community-based model for worldwide implementation.



 


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